Location: Food and Feed Safety Research
Title: Classification, Analysis, and Release of Aspergillus flavus Gene Index Consisting of 7,218 Expressed Unique Genes Authors
Submitted to: Germplasm Release
Publication Type: Other
Publication Acceptance Date: May 1, 2005
Publication Date: January 1, 2006
Citation: Yu, J., Cleveland, T.E., Bhatnagar, D., Nierman, W.C. 2006. Classification, Analysis, and Release of Aspergillus flavus Gene Index Consisting of 7,218 Expressed Unique Genes. In: The Institute for Genomic Research and The Dana Farber Cancer Institute (
Technical Abstract: Aflatoxins are the most potent natural toxins and carcinogens. These compounds, produced by Aspergillus flavus and A. parasiticus, contaminate pre-harvest agricultural crops in the field and post-harvest grains during storage. In order to devise strategies to reduce and eliminate aflatoxin contamination of food and feed, analysis and classification of the expressed genes in Aspergilllus flavus have been performed. From the nearly 20,000 Expressed Sequence Tags (ESTs), 7218 unique expressed open-reading frames (ORFs) have been assembled. The functional classification of these ORFs has been tentatively assigned based on the known sequences in the GenBank database using BLAST search software program. The Aspergillus flavus Gene Index was initially constructed and released at the website of The Institute for Genomic Research (TIGR) and is currently maintained and managed by The Dana Farber Cancer Institute of Harvard Medical School, Harvard University, Boston (http://compbio.dfci.harvard.edu/tgi/cgi-bin/tgi/gimain.pl?gudbhttp://compbio.dfci.harvard.edu/tgi/cgi-bin/tgi/gimain.pl?gudb=a_flavus=a_flavus). These sequence datum with their tentative functions assigned will be used directly by international researchers in their investigation on aflatoxin biosynthesis and for reducing aflatoxin contamination of agricultural commodities.