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Title: In vitro transformation properties of the Meq protein of MDV

Author
item AJITHDOSS, DHARANI - TEXAS A&M UNIVERSITY
item LUPIANI, BLANCA - TEXAS A&M UNIVERSITY
item Lee, Lucy
item REDDY, SANJAY - TEXAS A&M UNIVERSITY

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/18/2007
Publication Date: 7/18/2007
Citation: Ajithdoss, D., Lupiani, B., Lee, L.F., Reddy, S. 2007. In vitro transformation properties of the Meq protein of MDV [abstract]. American Association of Avian Pathologists/American Veterinary Medical Association Abstract. p. 124.

Interpretive Summary:

Technical Abstract: Marek's disease virus (MDV) type 1 is the causative agent of Marek's disease a T-cell lymphoma in chickens. In our laboratory, two MDV strains, Md5, and CVI988 are being investigated for mechanisms of tumor formation. Though both the strains express meq, a MDV oncogene, only Md5 but not CVI988 virus causes T cell lymphoma. We cloned meqs (Md5 meq, CVI988 meq & CVI988 long meq) in a retroviral system to study their in vitro transformation properties. All three Meq proteins induced morphological changes, focus formation, and colonies in soft agar in both rat-2 and NIH 3T3 cells.