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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #213851
Title: The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population

Author
item PEREZ-MARTINEZ, PABLO - UNIV OF REINA SOFIA, ES
item PEREZ-JIMENEZ, FRANCISCO - UNIV OF REINA SOFIA, ES
item Ordovas, Jose
item BELLIDO, CECILLIA - UNIV OF REINA SOFIA, ES
item MORENO, JUAN - UNIV OF REINA SOFIA, ES
item GOMEZ, PURIFICACION - UNIV OF REINA SOFIA, ES
item MARIN, CARMEN - UNIV OF REINA SOFIA, ES
item FRENANDEZ DE LA PUEB, RAFAEL - UNIV OF REINA SOFIA, ES
item PANIAGUA, JUAN - UNIV OF REINA SOFIA, ES
item LOPEZ-MIRANDA, JOSE - UNIV OF REINA SOFIA, ES

Submitted to: Nutrition Metabolism and Cardiovascular Disease
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/5/2007
Publication Date: 3/20/2007
Citation: Perez-Martinez, P., Perez-Jimenez, F., Ordovas, J.M., Bellido, C., Moreno, J.A., Gomez, P., Marin, C., Frenandez De La Puebla, R.A., Paniagua, J.A., Lopez-Miranda, J. 2007. The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population. Nutrition Metabolism and Cardiovascular Disease. 17(3):224-229.

Interpretive Summary: Blood cholesterol concentrations have been consistently associated with risk of heart disease. The levels of cholesterol are determined by combination of genetic and environmental factors such as dietary fat and cholesterol intakes. We report in this paper that the response of blood cholesterol to dietary fat may be partially determined by specific variation at the APOB gene. Specifically, we studied the how variation in this gene affected blood cholesterol concentrations as result of diets containing different fat content in 97 healthy volunteers. Our data suggest that some people are genetically predisposed to higher cholesterol blood levels when consuming high cholesterol and fat diets. These individuals may be at a higher risk for cholesterol-related diseases, such as obesity and heart disease.

Technical Abstract: Our goal was to determine whether the presence of the '516C/T polymorphism in the APOB gene promoter modifies the lipid response to changes in the amount and quality of dietary fat. We studied 97 young healthy volunteers (70 males and 27 females), 62 homozygotes for the '516C allele (C/C) (47 males and 15 females), 34 heterozygotes for the '516T allele (C/T) (22 males and 12 females) and one male homozygote for the '516T allele (T/T). Subjects consumed three different diets in successive 4-week dietary periods. During the first 28 days, all subjects consumed a saturated fatty acid (SFA)-rich diet (38% fat and 20% SFA). Then, using a randomized crossover design, subjects were assigned a carbohydrate (CHO)-rich diet (30% fat and 55% carbohydrate) or a monounsaturated fatty acid (MUFA)-rich diet (38% fat and 22% MUFA). At the end of each dietary period, plasma concentrations of triacylglycerols and of total, LDL, and HDL cholesterol were measured. No differences in plasma lipid and apolipoprotein response were found after changes in dietary fat intake in relation to the '516C/T polymorphism in our study population. In conclusion, our data suggest that the APOB '516C/T polymorphism has no effect on the lipid profile after changes in dietary fat intake in a healthy population.