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United States Department of Agriculture

Agricultural Research Service

Research Project: BIOLOGICAL CONTROL OF INSECTS AND MICROORGANISMS TO PREVENT MYCOTOXIN CONTAMINATION

Location: Foodborne Toxin Detection and Prevention

Title: The Structural Diversity of Phthalides from the Apiaceae

Authors
item Beck, John
item Chou, Shen-Chieh - UNIV. CO HEALTH SVC CNTR

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: March 30, 2007
Publication Date: May 4, 2007
Citation: Beck, J.J., Chou, S. 2007. The Structural Diversity of Phthalides from the Apiaceae. Journal of Natural Products. 70(5):891-900.

Interpretive Summary: Phthalides, and their corresponding dihydro and tetrahydro analogs, are components of several genera of the plant family Apiaceae. They have been reported as exhibiting a wide range of bioactivities against several illnesses and physiological conditions, including microbial and viral infections, strokes, tuberculosis, and vasoconstriction. Many of these genera are purported to possess medicinal values and of these several are considered to be traditional herbal medicines. This review provides an overview of the isolation, characterization, and bioactivity of phthalides, dihydrophthalides, tetrahydrophthalides, and dimers, from Apiaceae. The literature discussed is derived from readily accessible papers spanning the early 1960s to the present.

Technical Abstract: Phthalides, and their corresponding dihydro and tetrahydro analogs, are components of several genera of the plant family Apiaceae. These taxa have been reported as exhibiting a wide range of bioactivities against experimental models of several illnesses and physiological conditions, including microbial and viral infections, stroke, tuberculosis, and vasoconstriction. Many of these genera are purported to possess medicinal values and of these several are considered to be traditional herbal medicines. This review provides an overview of the methods of investigation, the structural diversity, and the bioactivity of phthalides, dihydrophthalides, tetrahydrophthalides, and dimers, from plants in the Apiaceae.

Last Modified: 7/24/2014
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