Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: July 1, 2007
Publication Date: N/A
Technical Abstract: Proteomics, the systematic study of the identities, quantities, structures, and biochemical and cellular functions of all proteins in a cell, tissue or organism, promised a rapid transformation for biological and medical research in the post-genomic era. Tremendous progress has been made over the past decade in this highly mass spectrometry dependent discipline of systems biology. Proteomics is regarded as a comprehensive research tool that is not only capable of identifying and quantifying large sets of proteins but also of determining their localization, interactions, modifications, activities, and functions. Recent developments in proteomics research that include protein separation methods, mass spectrometric instrumentation, computational analysis, and integrative databases will be reviewed with the focus on post-translational modifications. In light of the current status and the perspectives of proteomics applications, we will discuss the implications for future dairy protein research, such as in structural and functional studies of milk fat globule membrane proteins and other low abundance yet biologically important proteins in milk and dairy products.