Technical Abstract: No-till systems and crop residue management have changed cropping systems in the Central Great Plains. Previously, winter wheat-fallow was the prevalent rotation; now producers grow warm-season crops along with winter wheat and fallow. With this diversity of crops, producers have developed a multi-tactic approach to weed management where cultural tactics disrupt weed population growth. Producers using this approach are managing weeds with 50% less cost compared with the winter wheat-fallow rotation. Two key components of the multi-tactic approach are arranging cool- and warm-season crops in a cycle of four and using no-till practices. The cycle-of-four rotation also minimizes severity of plant diseases, thereby increasing yield potential of crops. Net returns are fourfold greater with crop diversity and no-till compared with winter wheat-fallow and tillage. Reduced cost with weed management comprised one half of the gain in net returns with no-till rotations and crop diversity.