Submitted to: Agricultural Experiment Station Publication
Publication Type: Experiment Station
Publication Acceptance Date: December 15, 2006
Publication Date: February 3, 2007
Citation: Lunney, J.K. 2007. BARC 2006 Experiment station report for NC-229 national project on Porcine Reproductive and Respiratory Syndrome (PRRS) control. Agricultural Experiment Station Publication.
The NC-229 national project “Porcine Reproductive and Respiratory Syndrome (PRRS): Methods for the integrated control, prevention, and elimination of PRRS in United States swine herds” This station report summarizes the BARC lab’s recent research progress on the first objective, virus replication in the individual host (e.g., host genetics, immunity, persistence, pathogenesis, viral genome, anti-virals, vaccinology). Three major projects have been addressed. 1) Based on a study of 400 pigs by U Nebraska and ARS BARC scientists genes encoding the innate cytokine interleukin-8 (IL8) and the anti-viral protein interferon-gamma (IFNG) may help determine whether pigs will effectively resist PRRS virus infection. These data outline targets for future studies to determine if specific immune gene alleles are associated with PRRS virus resistance; 2) Based on work with SD State scientists a North American Type 1 PRRSV infectious clone has been shown to stimulate immune responses similar to the parental type I PRRS virus; and 3) Work with samples collected at Iowa State Univ. for the “Big Pig” project have not yet highlighted any immune genes that might help prevent PRRS viral persistence. Overall this information will help producers to decrease breeding of PRRSV susceptible pigs, and potentially select for PRRSV resistant stock.