Title: Control of gene expression by mRNA transport and turnover Author
Submitted to: Regulation of Gene Expression in Plants: The Role of Transcript Structure and Processing
Publication Type: Book / Chapter
Publication Acceptance Date: September 14, 2006
Publication Date: February 7, 2007
Citation: Bassett, C.L. 2007. Control of gene expression by mRNA transport and turnover. In: Bassett, C.L., editors. Regulation of Gene Expression in Plants: The Role of Transcript Structure and Processing. New York, NY: Springer Life Sciences. p. 148-188. Technical Abstract: Genes are regulated primarily by their rate of transcript initiation. However, recent research in eukaryotic transcript degradation, export, and localization indicate that these processes contribute significantly to the amount of any given transcript in a cell. This review chapter looks at general and specific pathways of mRNA turnover in animal and plant cells. In addition, it focuses on the export and localization of mRNAs which also affect gene expression by sequestering mRNAs from active translation or by concentrating them to direct translation to specific intracellular regions. For each process, contemporary research in animal models is discussed relative to the most recent research in plants. This chapter provides scientists and students with an overview of current research in this area of gene expression control.