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ARS Home » Midwest Area » Peoria, Illinois » National Center for Agricultural Utilization Research » Mycotoxin Prevention and Applied Microbiology Research » Research » Publications at this Location » Publication #198312
Title: KOLOKOSIDES A-D: TRITERPENOID GLYCOSIDES FROM A HAWAIIAN ISOLATE OF XYLARIA SP.

Author
item DEYRUP, STEPHEN - UNIVERSITY OF IOWA
item GLOER, JAMES - UNIVERSITY OF IOWA
item O Donnell, Kerry
item Wicklow, Donald

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/31/2006
Publication Date: 2/7/2007
Citation: Deyrup, S.T., Gloer, J.B., O Donnell, K., Wicklow, D.T. 2007. Kolokosides A-D: Triterpenoid glycosides from a Hawaiian isolate of Xylaria sp. Journal of Natural Products. 70(3):378-382.

Interpretive Summary: Fungi adapted to long-term survival in arid environments offer a potential source of novel antifungal agents useful to agriculture and medicine. The wood decay fungus Xylaria sp. NRRL 40192, collected in a montane dry forest near Kailua-Kona, Hawaii, was examined for its ability to produce antifungal agents and other bioactive metabolites. Four new triterpenoid glycosides, kolokosides A-D, are reported. Kolokoside A exhibited antibacterial activity against Bacillus subtilis and Staphylococcus aureus.

Technical Abstract: Four new triterpenoid glycosides, kolokosides A-D (1-4), along with the known compound 19, 20-epoxycytochalasin N, were isolated from cultures of a Hawaiian wood-decay fungus (Xylaria sp.) The structures and relative configurations of 1-4 were determined primarily by analysis of NMR data, and the absolute configuration of 1 was assigned by application of the exciton chirality method. Compound 1 exhibited activity against gram-positive bacteria.