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United States Department of Agriculture

Agricultural Research Service

Research Project: METABOLIC VARIABLES AFFECTING THE EFFICACY, SAFETY, AND FATE OF AGRICULTURAL CHEMICALS

Location: Animal Metabolism-Agricultural Chemicals Research

Title: Degradation of Estradiol and Ethinylestradiol with Taml Oxidant Activator and Hydrogen Peroxide.

Authors
item Shappell, Nancy
item Ro, Kyoung
item Madsen, Peter - CARNEGIE MELLON INST
item Horowitz, Colin - CARNEGIE MELLON INST
item Hunt, Patrick
item Collins, Terrence - CARNEGIE MELLON INST
item Vrabel, Melanie - CARNEGIE MELLON INST

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: March 6, 2006
Publication Date: June 26, 2006
Citation: Shappell, N.W., Ro, K.S., Madsen, P., Horowitz, C., Hunt, P.G., Collins, T.J., Vrabel, M. 2006. Degradation of estradiol and ethinylestradiol with taml oxidant activator and hydrogen peroxide. Meeting Abstract. 10th Annual Green Chemistry & Engineering Conference, Washington, DC, June 26-30, 2006.

Technical Abstract: Endocrine disruptors have been found in our surface waters as a result of incomplete wastewater treatment and contamination from animal rearing facilities. Two identified contaminants with estrogenic activity are 17ß-estradiol (E2, the most potent natural estrogenic hormone) and 17alpha-ethinylestradiol (EE2, the synthetic estrogen found in most birth control pills). A peroxide-activating catalyst Fe-TAML® (TAML® is tetraamido macrocyclic ligand) was evaluated for its capacity to degrade these compounds. While EE2 is resistant to most biological degradation processes, the Fe-TAML catalyst plus hydrogen peroxide (pH 10) resulted in degradation of greater than or equal to 95% within 5 minutes at room temperature (by HPLC analysis). Similar degradation was observed with E2 when the Fe-TAML:E2 ratio was 1:250, while degradation kinetics were measurable using ratios of 1:1000. The reaction closely followed first-order decay kinetics. Using LC MS-MS, neither estrogenic metabolite estrone nor estradiol were detected post-reaction. These results indicate a potential use for Fe-TAML in remediation of municipal and agricultural wastewater containing estrogenic compounds.

Last Modified: 7/25/2014
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