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Title: EFFECT OF VITAMIN E ON PROSTACYCLIN (PGI2) AND PROSTAGLANDIN (PG) E2 PRODUCTION BY HUMAN AORTA ENDOTHELIAL CELLS: MECHANISM OF ACTION

Author
item WU, DAYONG - 8050-00-00
item LIU, LIPING - 8050-00-00
item MEYDANI, MOHSEN - 8050-00-00
item MEYDANI, SIMIN - 8050-00-00

Submitted to: Annals of the New York Academy of Sciences
Publication Type: Review Article
Publication Acceptance Date: 11/18/2004
Publication Date: 12/14/2004
Citation: Wu, D., Liu, L., Meydani, M., Meydani, S.N. 2004. Effect of vitamin E on prostacyclin (PGI2) and prostaglandin (PG) E2 production by human aorta endothelial cells: Mechanism of action. Annals Of The New York Academy Of Sciences. 1031:425-427.

Interpretive Summary:

Technical Abstract: Vitamin E has been suggested to reduce the risk of cardiovascular diseases. Prostanoids are vasoactive molecules, the change in whose production contributes to homeostasis and pathophysiology of the cardiovascular system. In the current study, we determined the effect of vitamin E on production of vasodilative PGI2 and PGE2 by human aorta endothelial cells (HAECs) and its underlying mechanism. Results showed that vitamin E increased production of both prostanoids by HAECs. This effect of vitamin E is due to increased release of substrate arachidonic acid, which in turn results from increased expression of phospholipase A2 (PLA2).