ARS | Publication request: BIOLOGICAL ACTIVITY OF LYCOPENE AGAINST SMOKE-INDUCED LUNG LESIONS: TARGETING IGF-I/IGFBP-3 SIGNAL TRANSDUCTION PATHWAY

Submitted to: Carotenoids and Retinoids: Molecular Aspects and Health Issues
Publication Type: Book / Chapter
Publication Acceptance Date: November 5, 2004
Publication Date: January 1, 2005
Citation: Wang, X. 2005. Biological activity of lycopene against smoke-induced lung lesions: targeting igf-i/igfbp-3 signal transduction pathway. In: Packer, L., Obermueller-Jevic, U., Kraemer, K., Sies, H. Editors. Champaign, Illinois, USA. Carotenoids and Retinoids: Molecular Aspects and Health Issues. AOCS Press, p. 168-181.

Technical Abstract: The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell proliferation, differentiation, and apoptosis. Disruptions of normal IGF-I system components leading to hyperproliferation and survival signals have been implicated in the development of different tumor types. This book chapter will focus on recent evidence that lycopene exerts its protective effects against smoke-induced lung carcinogenesis through up-regulating IGFBP-3 as a molecular target, interrupting the signal transduction pathway of IGF-1, inhibiting cell proliferation, and promoting apoptosis. In addition, the issue regarding the alteration of lycopene metabolism in smoke-exposed lung tissue is discussed.