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United States Department of Agriculture

Agricultural Research Service

Title: Carotenoid and Retinoid Metabolism: Insights from Isotope Studies

Authors
item Burri, Betty
item Clifford, Andrew - UNIV.CALIF.DAVIS, NUTR.

Submitted to: Archives Of Biochemistry and Biophysics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: May 28, 2004
Publication Date: May 28, 2004
Citation: Burri, B.J., Clifford, A.J. Carotenoid and retinoid metabolism: insights from isotope research. Archives Of Biochemistry and Biophysics 430 (2004) 110-110.

Interpretive Summary: We summarize and discuss the insights into the absorption and metabolism of vitamin A, beta-carotene, and lutein that were gained with the use of isotope tracers in humans and rats. We review recent developments in vitamin A and beta-carotene research using these advanced scientific methods.

Technical Abstract: Use of isotopes as tracers have had an important role in elucidating key features of vitamin A and retinoid metabolism in animal models and humans. Their use has shown that B-carotene absorption is variable, and that that the appearance of B-carotene, and its metabolites in the blood by time since dosing follow characteristic patterns. Retinol formed from B-carotene shows a different pattern, as does lutein. In this article we summarize and discuss the insights into the absorption and metabolism of vitamin A, B-carotene, and lutein that were gained with the use of isotope tracers in humans and rats. This research review summarizes recent developments on carotenoid and retinoid absorption, metabolism and excretion.

Last Modified: 11/22/2014
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