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Title: REGULATION OF PLASMA GLUCOSE AND PEPTIDE HORMONES BY SOYBEAN ISOFLAVONES AND PROBIOTICS IN A RAT MODEL OF TYPE II DIABETES (POSTER: 44TH ANNUAL MTG, AM. COLLEGE OF NUTRITION, NASHVILLE, TN, OCT 9-12, 2003)

Author
item Bhathena, Sam
item ALI, ALI - VA ST UNIV, PETERSBURG
item MOHAMED, A - VA ST UNIV,PETERSBURG
item HANSEN, C - NIH, BETHESDA, MD
item VELASQUEZ, MANUEL - GW UNIV, WASHINGTON,DC

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 10/31/2003
Publication Date: 10/31/2003
Citation: Bhathena, S.J., Ali, A.A., Mohamed, A.I., Hansen, C.T., Velasquez, M.T. 2003. Regulation of plasma glucose and probiotics in a rat model of type II diabetes. Journal of the American College of Nutrition. 22:475.

Interpretive Summary:

Technical Abstract: Soybean has beneficial effect in obesity and diabetes. We tested the hypothesis that the beneficial effects are due in part to the modulation of peptide hormones involved in glucose metabolism and obesity by isoflavones, the major phytochemicals in soybean. Lean and obese SHR/N-cp rats were fed AIN-93 diets containing 20% casein (controls) or 20% casein supplemented with 0.1% soybean isoflavones (I), or 0.1 % probiotic mixture (P), or 0.1% mixture of I and P (I+P). Plasma was analyzed for glucose and peptide hormones. Different fat depots were excised and weighed. The total body fat content was lower in rats fed I and I+P comparted to those fed casein or P diets. I, but not P, lowered plasma glucose in both lean and obese phenotypes and lowered ACTH in obese rats. I also lowered plasma insulin, glucagon and leptin in lean rats but not obese rats. P and P+I increased insulin in obese rats and decreased plasma ACTH in lean rats. In conclusion, isoflavones have beneficial effects in obesity and on glucose metabolism. The beneficial effect appears in part to be due to modulation of peptide hormones.