CHARACTERIZATION OF THE MAREK'S DISEASE VIRUS LORF-10 GENE

Authors: Silva, Robert; LUPIANI, BLANCA - TEXAS A&M UNIVERSITY; REDDY, SANJAY - TEXAS A&M UNIVERSITY

Submitted to: World Veterinary Poultry Association Congress Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 7/19/2003
Publication Date: 7/31/2003
Citation: Silva, R.F., Lupiani, B.M., Reddy, S. 2003. Characterization of the marek's disease virus LORF-10 gene. World Veterinary Poultry Association Congress Proceedings. p. 101.

Interpretive Summary:

Technical Abstract: DNA sequencing of the GA and Md5 strains of Marek's disease virus (MDV) revealed several open reading frames (ORFs) that are either unique to MDV or have homologues in only a few other herpesviruses. LORF-10, located in the unique long region of the serotype 1 MDV genome, has a homologue in turkey herpes virus, but apparently no homologue in serotype 2 MDVs. We plan to characterize the LORF-10 gene by identifying its protein product and evaluating its function by using a LORF-10 deleted Md5 virus.