Author
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MEYDANI, MOHSEN - HNRCA |
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Submitted to: Nutrition Reviews
Publication Type: Review Article Publication Acceptance Date: 12/1/2002 Publication Date: 2/10/2003 Citation: MEYDANI, M. SOLUABLE ADHESION MOLECULES, SURROGATE MARKERS OF CARDIOVASCULAR DISEASE?. NUTRITION REVIEWS. 61(2):63-8,2003. Interpretive Summary: Technical Abstract: Adhesion molecules expression on the surface of endothelial and immune cells are important for immune and endothelial cells interaction during the inflammatory process. Several of these adhesion molecules have been identified and are believed to be important in the pathogenesis of atherosclerosis. The soluble forms of adhesion molecules (sCAMs) are shed from cell surfaces or generated as splice variants and released into blood circulation. The elevated level of adhesion molecules in circulation is conceived to be due to immune and/or endothelial cells¿ activation and disease activity. The increased expression of several adhesion molecules in the atherosclerotic lesions and in the circulation of patients having high risks factors for atherosclerosis and myocardial infarction has been reported. Measurement of sP-selectin might be used as molecular marker of platelet aggregation and thrombus formation in acute coronary syndrome. Whereas, elevated levels of sE-selectin may relate to the early stage of angina. Measuring sICAM-1 in elderly patients may assist in diagnosing silent cerebral infarction, while monitoring its level following angioplasty might be a useful predictor of myocardial ischemia/reperfusion injury in patients with acute myocardial infarction. The increased level of sICAM-1, but not sVCAM-1, has been suggested to be used as a predictor or an early marker of a high risk for myocardial infarction. Experimental and some clinical data have indicated that supplemental intake of fish oil or vitamin E may lower the risk of cardiovascular disease by reducing expression of some of the adhesion molecules. |
