|Zakhartchouk, A - LEIDEN, THE NETHERLANDS|
|Bout, A - LEIDEN, THE NETHERLANDS|
|Woods, L - UNIV. OF CALIF., DAVIS|
|Havenga, M - LEIDEN, THE NETHERLANDS|
Submitted to: Archives of Virology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: November 22, 2001
Publication Date: May 23, 2002
Citation: ZAKHARTCHOUK, A., BOUT, A., WOODS, L.W., LEHMKUHL, H.D., HAVENGA, M.J. BRIEF REPORT: ODOCOILEUS HEMIONUS DEER ADENOVIRUS IS RELATED TO THE MEMBERS OF ATADENOVIRUS GENUS. ARCHIVES OF VIROLOGY. 2002. V. 147(4); p. 841-847. Interpretive Summary: Deer adenovirus produces lesions in blood vessels that can be extremely lethal for mule deer. To characterize the virus, part of the virus genetic material was examined. Analysis of the DNA revealed similarities to several other adenoviruses. The highest similarity was found with the members of the proposed Atadenovirus genus: ovine adenovirus isolate 287, bovine adenovirus 4, and duck adenovirus 1. These data suggest that OdAdV-1 is a member of the Atadenovirus genus.
Technical Abstract: The Odocoileus hemionus deer adenovirus (OdAdV-1) causes systemic and local vasculitis and proves extremely lethal for mule deer. To characterize the virus, part of the genome flanking the fiber gene was cloned and sequenced. The sequence revealed two open-reading frames that mapped to pVIII hexon-associated protein precursor and fiber protein of several other adenoviruses. The highest amino acid homology for pVIII and fiber was found with the members of the proposed Atadenovirus genus: ovine adenovirus isolate 287 (OAdV-287), bovine adenovirus 4 (BAdV-4) and duck adenovirus 1 (DAdV-1). The homology with bovine adenovirus type 3 (BAdV-3) proved low. The E3 region was not found between the gene for pVIII and fiber. These data suggest that OdAdV-1 is a member of the Atadenovirus genus.