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United States Department of Agriculture

Agricultural Research Service

Title: Identification of Swainsonine As a Glycoside Inhibitor Responsible for Sida Carpinifolia Poisoning

Authors
item Colodel, Edson - FFUFMT, BRAZIL
item Gardner, Dale
item Driemmeier, David - UFRGS, BRAZIL
item Zlotowski, Priscila - UFRGS, BRAZIL

Submitted to: Veterinary and Human Toxicology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: February 20, 2002
Publication Date: June 20, 2002
Citation: COLODEL, E.N., GARDNER, D.R., DRIEMMEIER, D., ZLOTOWSKI, P. IDENTIFICATION OF SWAINSONINE AS A GLYCOSIDE INHIBITOR RESPONSIBLE FOR SIDACARPINIFOLIA POISONING. VETERINARY AND HUMAN TOXICOLOGY. 2002.

Interpretive Summary: The alkaloid swainsonine has been identified as the toxic constituent of Sida carpinifolia, a native perennial shrub-like plant, which as been reported to produce neurological disorders in goats and ponies in southern Brazil. Swainsonine was detected in dry ground plant material after extraction and analysis using previously developed analytical procedures. The swainsonine concentration was measured and found to be 0.006% on a dry weight basis. The clinical and pathological features of this lysosomal storage disease were similar to those observed in locoweed and Swainsona poisonings.

Technical Abstract: The indolizidine alkaloid swainsonine has been identified as the toxic constituent of Sida carpinifolia, a native perennial shrub-like plant, which has been reported to produce neurological disorders in goats and ponies in southern Brazil. Swainsonine was detected in dry ground plant material after extraction and analysis by both liquid and gas chromatography mass spectrometry. The swainsonine concentration was measured and found to be 0.006% on a dry weight basis. The clinical and pathological features of this lysosomal storage disease were similar to those observed in Swainsona, Oxytropis, Astragalus, and Ipomoea poisonings. The most important pathological findings were multiple cytoplasm vacuoles in neurons, acinar pancreatic cells, hepatocytes, and renal tubular cells.

Last Modified: 11/25/2014
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