ARS | Publication request: SYNTHESIS OF (DIETHYL-D10) COUMAPHOS AND RELATED COMPOUNDS

Submitted to: American Chemical Society Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: July 18, 2000
Publication Date: N/A

Technical Abstract: Two deuterated insecticides were prepared for use as internal standards for GLC/mass spectrometric analyses. Diethyl chlorothiophosphate-d10 was prepared by reaction of ethanol-d6 with P2S5 to give labeled diethyldithiophosphoric acid, followed by chlorination. Treatment of the acid chloride with 3-chloro-4-methyl-7-hydroxycoumarin and potassium carbonate in refluxing acetone gave labeled coumaphos. An analogous reaction with 4-methyl-7-hydroxycoumarin gave labeled potasan, and the technique can be used for synthesis of labeled forms of most dialkyl thiophosphate insecticides.