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United States Department of Agriculture

Agricultural Research Service

Title: Implantation in Ruminants: Changes in Pre-Implantation, Maternal Recognition of Pregnancy, Control of Attachment and Invasion

item Nagaoka, Kentaro - UNIV TOKYO, JAPAN
item Yamaguchi, Hirohito - UNIV TOKYO, JAPAN
item Aida, H - UNIV TOKYO, JAPAN
item Yoshioka, K - UNIV TOKYO, JAPAN
item Takahashi, M - UNIV TOKYO, JAPAN
item Christenson, Ronald
item Imakawa, Kazuhiko - UNIV TOKYO, JAPAN
item Sakai, Senkiti - UNIV TOKYO, JAPAN

Submitted to: Asian Australasian Journal of Animal Sciences
Publication Type: Review Article
Publication Acceptance Date: December 20, 1999
Publication Date: June 20, 2000
Citation: Nagaoka, K., Yamaguchi, H., Aida, H., Yoshioka, K., Takahashi, M., Christenson, R.K., Imakawa, K., Sakai, S. 2000. Implantation in ruminants: Changes in pre-implantation, maternal recognition of pregnancy, control of attachment and invasion. Asian-Australasian Journal of Animal Sciences. 13(6):845-855.

Technical Abstract: As high as 50% of pregnancies are known to fail and the majority of such losses occur during the peri-implantation period. For the establishment of pregnancy in mammalian species, therefore, implantation of the conceptus to the maternal endometrium must be completed successfully. Physiological events associated with implantation differ among mammals. In ruminant ungulates, an elongation of the trophectoderm in early conceptus development is required before the attachment of the conceptus to the uterine endometrium. Moreover, implantation sites are restricted to each uterine caruncula where tissue remodeling, feto-maternal cell fusion and placentation take place in a coordinated manner. These unique events occur under strict conditions and are regulated by numerous factors from the uterine endometrium and trophoblast in a spatial manner. Interferon-tau (IFN-tau), a conceptus-derived anti-luteolytic factor, which rescues corpus sluteum from its regression in ruminants, is particularly apt to play an important role as a local regulator in coordination with other factors, such as TGF-beta, Cox-2 and MMPs at the attachment and placentation sites.

Last Modified: 4/22/2015
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