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United States Department of Agriculture

Agricultural Research Service

Title: Cytokines Orchestrating the Immune Response

Author
item Lunney, Joan

Submitted to: OIE Scientific and Technical Review: Contamination of Animal Products
Publication Type: Literature Review
Publication Acceptance Date: July 22, 1998
Publication Date: N/A

Interpretive Summary: This review summarizes the current knowledge of the major immune cytokines, their receptors and functions. It illustrates the pivotal role of cytokines in regulating immune responses. As researchers explore the factors which influence the genetics of disease resistance in livestock and poultry they will inevitably be defining alleles associated with differences in expression of, and responsiveess to, cytokines. Variations in cytokine receptors, as well as in sensitivity to the rapidly expanding array of cytokine agonists and antagonists, will also be identified. These differences influence not only disease resistance but also potential disease pathology and speed of recovery from infection. The review will conclude with some uses of cytokines in clinical practice. This area is the subject of active exploration with clinical trials in many species addressing issues such as immune system stimulation, and disease treatment, ,with cytokine proteins. As veterinarians use such new biotherapeutics the issue of genetic control of responses to deliberate cytokine stimulation will become important to producers.

Technical Abstract: The author summarises the current knowledge of the major immune cytokines, their receptors and functions, and illustrates the pivotal role of cytokines in regulating immune responses. As researchers explore the factors which influence the genetics of disease resistance in livestock and poultry, alleles associated with differences in the expression of, and responsiveness to, cytokines will inevitably be defined. Variations in cytokine receptors, as well as in sensitivity to the rapidly expanding array of cytokine agonists and antagonists, will also be identified. These differences influence not only disease resistane but also potential disease pathology and speed of recovery from infection. The author concludes with a discussion of some uses of cytokines in clinical practice. This area is the subject of active exploration with clinical trials in many species, addressing issues such as immune system stimulation and disease treatment with cytokine proteins. As veterinarians use such new biotherapeutics, th issue of genetic control of responses to deliberate cytokine stimulation will become important to producers.

Last Modified: 9/23/2014
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