|Park, Yong-Ho - SEOUL NATIONAL UNIV|
|Hahn, Jae-Yong - SEOUL NATIONAL UNIV|
|Oh, Bong-Kuk - NATL VET RES INST|
|Moon, Jin-San - NATL VET RES INST|
|Koo, Bok-Kyeong - NATL VET RES INST|
|Joo, Yi-Seok - NATL VET RES INST|
|Seo, Keun-Seok - SEOUL NATIONAL UNIV|
|Davis, William - WASH STATE UNIV|
Submitted to: Korean Journal of Veterinary Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: July 30, 1998
Publication Date: N/A
Interpretive Summary: Effective control of poultry diseases by host immune system requires the activation of effector mechanisms which destroy invading pathogens. Due to an increasing understanding of how the immune system is regulated in disease situations, research activity in this area is increasing. In this study, ARS scientists, in collaboration with scientists at the Seoul National University, examined different breeds of chickens with respect to their lymphocyte subpopulations. The results show that differences in the lymphocyte phenotypes exist among the breeds of chickens examined. This information will be used to identify the lymphocyte phenotype which is associated with genetically controlled disease resistance in chickens.
Technical Abstract: The immunogenetic analysis was performed to characterize the Korean native chickens (KNC) using monoclonal antibodies specific to chicken leukocyte differentiation antigens and flow cytometry. A total of 174 chickens including 58 KNC (black, brown and dark-brown colored), 77 foreign breed (Nagoya, White Leghorn, Rhode Island and Cornish) and 39 mixed breed (19 KNC with Nagoya and 20 KNC with Rhode Island) which are maintained at Animal Science and Technology Institute were examined. The proportion of cells expressing MHC class II molecule (B-L in chicken) was significantly higher in KNC. Proportion of CD4+ T helper cells was also higher in KNC and in the two mixed breed than that in the foreign breed. However, proportion of CD8 cells and TCR1+ (gamma,delta T cell receptor) cells was the lowest among the breeds examined. Although genotypic analysis was not pursued in the KNC chickens, difference of phenotypic expression based on leukocyte differentiation molecules could be demonstrated in the KNC chickens in this study.