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United States Department of Agriculture

Agricultural Research Service

Title: Invasive Pulmonary Disease Caused by Neosartorya Pseudofischeri, Aspergillus Niger, and Aspergillus Fumigatus

Authors
item Kammeyer, P - LOYOLA UNIVERSITY
item Peterson, Stephen
item Stiff, P - LOYOLA UNIVERSITY
item Yong, S - LOYOLA UNIVERSITY
item Husain, A - LOYOLA UNIVERSITY
item O'Keefe, J - LOYOLA UNIVERSITY
item Carey, R - LOYOLA UNIVERSITY
item Bayer, R - LOYOLA UNIVERSITY
item Kharzo, M - LOYOLA UNIVERSITY
item Yeldandi, V - LOYOLA UNIVERSITY

Submitted to: American Society for Microbiology
Publication Type: Abstract Only
Publication Acceptance Date: May 21, 1998
Publication Date: N/A

Technical Abstract: A 27-year-old man underwent allogenic bone marrow transplant for chronic myelogenous leukemia. Four months after the procedure, the patent was admitted for treatment of pneumonia. Sputum cultures revealed Aspergillus niger and A. fumigatus. Amphotericin B lipid complex, itraconazole and sargramostim treatments were initiated. Two weeks later, bronchoscopic brush biopsy cultures revealed the presence of Aspergillus niger, A. fumigatus and Neosartorya pseudofischeri, suggesting invasive growth of fungi in lung tissue. N. pseudofischeri is rarely reported from human infections, and initially may resemble A. fumigatus, but is distinguished by ascocarp growth on culture plates. Its identity must be confirmed by scanning electron microscopy of the ascospore ornamentation which is unique and species-specific, or by sequencing of the internal transcribed spacer regions of the ribosomal DNA. Sequences of this and the ex type strain of N. pseudofischeri are in GenBank.

Last Modified: 9/22/2014
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