|Lindsay, David - VIRGINIA TECH|
|Speer, C. - MONTANA STATE UNIV|
Submitted to: Clinical Microbiological Reviews
Publication Type: Review Article
Publication Acceptance Date: February 1, 1998
Publication Date: N/A
Technical Abstract: Infections by the protozoan parasite, Toxoplasma gondii, are widely prevalent worldwide in animals and human beings. This paper reviews the life cycle, structure of tachyzoites, bradyzoites, oocysts, sporocysts, sporozoites and enteroepithelial stages of T. gondii, and the mode of penetration of T. gondii. This review provides a detailed account of the biology of tissue cysts and bradyzoites including in vivo and in vitro development, methods of separation from host tissue, tissue cyst rupture, and relapse. The mechanism of in vivo and in vitro stage conversion from sporozoites to tachyzoites to bradyzoites and from bradyzoites to tachyzoites to bradyzoites is also discussed.