Submitted to: North Central Avian Disease Conference
Publication Type: Proceedings
Publication Acceptance Date: September 9, 1997
Publication Date: N/A
Technical Abstract: Commercially-raised turkeys are exposed to a mixture of airborne contaminants which may lower resistance to infectious agents and lead to pulmonary pathology. Bacterial and fungal elements are major constituents of dust inhaled by turkeys. This study addresses the potential of LPS purified from Pasteurella multocida to cause pulmonary pathology or exacerbate lesions produced by gamma-irradiated nonviable A. fumigatus conidia when administered via the intra-air sac route. LPS provoked airsacculitis, pleuritis, and pneumonia following intra-air sac injection. LPS appeared to inhibit clearance of nonviable A. fumigatus conidia from pulmonary tissues. LPS in combination with A. fumigatus conidia resulted in accelerated pulmonary inflammation. Nonviable conidia do not elicit multinucleate giant cells, which are a feature of the inflammatory process in A. fumigatus infection. This study presents a model of aseptic airsacculitis and pneumonia with potential clinical relevance.