Submitted to: Research Workers in Animal Diseases Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: November 10, 1997
Publication Date: N/A
Technical Abstract: Bovine viral diarrhea virus (BVDV) has been reported to increase the virulence of other viral pathogens in dual infections. It is not known if this increased virulence is due to an interaction between BVDV and the host or a direct interaction between BVDV and the second pathogen. Recently, it has been shown that attenuated transmissible gastroenteritis virus (TGE) exhibits a virulent pathotype in the presence of a contaminating genotype 1 BVDV. Comparison of viral polypeptide expression in cultured cells infected with TGE alone or dually infected with TGE and BVDV revealed size shifts in TGE viral polypeptides. Similar shifts were observed between viral polypeptides produced in cell cultures infected with virulent or attenuated TGE. These shifts were not observed when cell cultures were dually infected with other pestiviruses or BVDV from other genotypes. These results suggest an interaction between BVDV and TGE at the cellular or molecular level.