|Schito, M - UNIV OF GUELPH, CANADA|
|Barta, J - UNIV OF GUELPH, CANADA|
Submitted to: Coccidiosis International Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: September 30, 1998
Publication Date: N/A
Technical Abstract: Recent studies on intracellular parasite infections in mice revealed the importance of cytokines in controlling the outcome of host immunity. Since several strains of cytokine knock-out mutant mice are now available, this study was conducted to investigate the role of interleukin-12 (IL-12), IL-10, and interferon-genome (IFN-g) in Eimeria vermiformis infection. IFN-g, IL-12 and IL-10 gene knock-out mice and their wild type controls were infected with 5,000 to 10,000 oocysts of Eimeria vermiformis, and oocyst production assessed from 7 to 14 days post-primary and post-secondary infections. Secondary infections were given 30 days following primary infection. The results showed that IL-12 and IFN-g, but not IL-10, are criticala for development of protective immunity to primary and secondary infections with E. vermiformis.