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United States Department of Agriculture

Agricultural Research Service

Title: Invasive Pulmonary Disease Caused by Neosartorya Pseudofischeri, Aspergillus Niger, and Aspergillus Fumigatus

Authors
item Yeldani, V - LOYOLA UNIVERSITY
item O'Keefe, J - LOYOLA UNIVERSITY
item Peterson, Stephen
item Yong, S - LOYOLA UNIVERSITY
item Husain, A - LOYOLA UNIVERSITY
item Carey, R - LOYOLA UNIVERSITY
item Stiff, P - LOYOLA UNIVERSITY
item Bayer, R - LOYOLA UNIVERSITY
item Solans, E - LOYOLA UNIVERSITY
item Kharzo, M - LOYOLA UNIVERSITY

Submitted to: International Congress of Mycology Proceedings and Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: June 13, 1997
Publication Date: N/A

Technical Abstract: A 28 year old man underwent allogenic bone marrow transplant for chronic myelogenous leukemia. His course was complicated by graft vs host disease and HSV and CMV disease. He presented four months after transplant with fever, cough and pulmonary infiltrates. Sputum cultures grew A. fumigatus and A. niger. Treatment with amphotericin B lipid complex, itraconazole and GMCSF was initiated. Two weeks after admission he underwent bronchoscopy with lavage and brush biopsies. Smears of the lavage revealed organisms consistent with Aspergillus. Fungal cultures of both the lavage and biopsy revealed A. fumigatus, A. niger, and Neosartorya sp. Three weeks after admission he developed K pneumoniae bacteremia. Despite aggressive therapy with broad spectrum antibacterial agents the patient succumbed to multi-organ system failure. The Neosartorya was sent for species identification to the USDA Laboratories in Peoria, IL. The organism was identified as Neosartorya pseudofischeri based on light microscopy of the sporulating fungus, by DNA sequencing and with scanning electron microscopy of the ascospores. Neosartorya pseudofischeri is rarely isolated from humans. This represents the third reported isolation of this organism from a human respiratory site.

Last Modified: 12/21/2014
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