Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: April 18, 1997
Publication Date: N/A
Technical Abstract: Immune protection of young turkeys given splenocytes from adult turkeys which had convalesced from pulmonary aspergillosis was assessed. Recipients were challenged, 16 hours after splenocyte transfer, with Aspergillus fumigatus by unilateral intra-air sac inoculation (IA; experiment 1) or intravenously (IV; experiment 2). Lesion scores post-challenge revealed no differences between turkeys given splenocytes from convalescent versus naive (control) turkeys. IA exposure produced ipsilateral lesions in air sacs and lung, whereas IV exposure produced severe miliary hepatitis. Donor cell function was confirmed by mitogen blastogenesis; however, cells were non-responsive to A. fumigatus antigens, regardless of exposure status.