|Hu, Zhiliang - UNIV. ILLINOIS (MARC)|
|Murtaugh, Michael - UNIV. MINNESOTA|
Submitted to: Mammalian Genome
Publication Type: Abstract Only
Publication Acceptance Date: March 25, 1997
Publication Date: N/A
Technical Abstract: High resolution microsatellite (MS) based genetic maps of swine provide a useful tool in mapping economically important loci (QTL) and marker assisted selection (MAS). The merging of the swine genetic and cytogenetic maps has also relied chiefly on MS. However, positional candidate cloning of genes accounting for significant genetic variation of a QTL ultimately requires alignment of the human and swine maps. At present, the swine linkage map incorporates only a limited number of comparative markers. The X chromosome has no genes with linkage data. We studied three genes assigned to the X chromosome in humans and cloned in pigs to initiate the comparative linkage map for the X chromosome. In this study, we linked hypoxanthine phosphoribosyltransferase (HPRT1) assigned to HSA Xq26.1, coagulation factor IX (F9), responsible for X-linked hemophilia in man assigned to HSAXq 26.3-27.1, and the Vitamin D-dependent calcium-binding protein (CALB3), or calbindin-D9k assigned to HSAXp 22.2 on the porcine X chromosome. These results provide the first linked, comparative reference loci for the X chromosome in swine.