Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: February 21, 1997
Publication Date: N/A
Technical Abstract: Pasteurella multocida is a pathogenic bacterium that produces septicemic or respiratory diseases in domesticated and wild animals. Five distinct groups (A,B,D, E and F) can be distinguished by serology. The presence of a capsule contributes significantly to virulence of P. multocida and its survival in a host. Non-antigenic mucopolysaccharides associated with capsules of some strains may provide a mechanism for attaching the bacteri to host cells as well as protecting them from host cell killing. Some strains produce a toxin that will produce turbinate atrophy in swine. Protection against P. multocida is mediated primarily by antibodies. Antibodies against the protein toxin neutralize its toxic effects and protect against turbinate atrophy. Bacterins and live-attenuated vaccines are used to control diseases caused by P. multocida. Bacterins consisting of formalin-killed organisms in a water-in-oil emulsion produce a long duration of protection. Whereas protection produced by bacterins is largely serotype specific, live-attenuated vaccines can protect against a variety of serotypes.