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United States Department of Agriculture

Agricultural Research Service

Title: Use of Large Insert Genomic Libraries in Livestock Gene Mapping

Author
item Smith, Timothy

Submitted to: Journal of Animal Science Supplement
Publication Type: Abstract Only
Publication Acceptance Date: June 10, 1996
Publication Date: N/A

Technical Abstract: The use of markers from the genetic maps of livestock species has the potential to significantly increase the efficiency of selection for desirable traits or against undesirable phenotypes. Microsatellite markers have shown to be the most polymorphic, easily genotyped class of markers, and form the basis for the major livestock maps. The usefulness of these maps in finding markers for trait loci depends on the extent of genome coverage, as well as marker density and ease of genotyping. Large insert libraries have been used to assess genome coverage by providing physical anchors that tie the cytogenetic map to the linkage map, and to increase marker density in the vicinity of loci affecting traits of interest. The ability to increase marker density around trait loci is especially critical in the application of markers to management of existing herds and germplasm, since many markers that are polymorphic in the mapping pedigrees are not universally informative.

Last Modified: 9/22/2014
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