Submitted to: Animal Genetics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: May 29, 1995
Publication Date: N/A
Interpretive Summary: The workshop permitted integration of mapping data between multiple laboratories for a single swine chromosome and established linkage maps for swine chromosome 6 suitable for initial QTL analysis.
Recent advances in the use of microsatellite markers and the development of comparative gene mapping techniques have made the construction of high resolution genetic maps of livestock species possible. Framework and comprehensive genetic linkage maps of porcine chromosome 6 have resulted from the first international effort to integrate genetic maps from multiple laboratories. Eleven highly polymorphic genetic markers were exchanged and mapped by four independent laboratories on the total of 583 animals derived from four reference populations. The chromosome 6 framework map consists of 10 markers ordered with high local support. The average marker interval of the framework map is 15.1 cM (sex averaged). The framework map is 135, 175 and 109 cM in length (for sex averaged, female and male maps, respectively). The comprehensive map includes a total of 48 type I and type II markers with a sex averaged interval of 3.5 cM and is 166, 196 and 126 cM (for sex averaged, female and male maps, respectively). Additional markers within framework map marker intervals can thus be selected from the comprehensive map for further analysis of quantitative trait loci (QTL) located on chromosome 6. The resulting maps of swine chromosome 6 proved a valuable tool for analyzing and locating QTL.