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United States Department of Agriculture

Agricultural Research Service

Title: Clinical Significance of Genetic Variation among Bovine Viral Diarrhea Viruses

item Bolin, Steven

Submitted to: Journal of Veterinary Medicine
Publication Type: Review Article
Publication Acceptance Date: July 18, 1996
Publication Date: N/A

Technical Abstract: Modern technology has allowed genetic analysis of BVDV. A result of this analysis has been the identification of two genotypes of BVDV. Viruses in either genotype may be noncytopathic or cytopathic in cell culture, and viruses in either genotype induce all of the disease processes collectively termed BVD. Significant antigenic differences exist between viral genotypes. Those antigenic differences appear to permit virus of one genotype to escape neutralization by antibody induced by inactivated virus of the other genotype. Currently, most outbreaks of severe disease are associated with type 2 BVDV, but it is likely that virulent type 1 BVDV also exist. Protection from type 2 BVDV is conferred by vaccines containing type 1 BVDV, but protection requires maintenance of detectable concentrations of type 2 BVDV specific antibody.

Last Modified: 4/22/2015
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