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United States Department of Agriculture

Agricultural Research Service

Title: Manganese Nutriture Affects Changes in Bone Mineral Element Composition Induced by Boron Deprivation

Author
item Nielsen, Forrest

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: January 4, 1996
Publication Date: N/A

Technical Abstract: Both boron (B) and manganese (Mn) apparently have roles in bone growth and maintenance. Moreover, some findings suggest that these roles can be related. Thus, a factorially arranged experiment was performed in which male Sprague-Dawley rats were assigned to groups of 10 and fed for about 9 weeks a casein - ground corn - corn oil based diet containing per kg about 0.09 mg B and 0.10 mg Mn. The dietary variables were supplemental B at 0 and 3 mg/kg and Mn at 0 and 20 mg/kg. Boron deprivation increased femur copper and potassium, and did not affect zinc concentrations in Mn- deficient rats, but did not affect copper, and decreased potassium and zinc concentrations in Mn-supplemented rats. Boron deprivation increased femur phosphorus concentrations in Mn-supplemented but not Mn-deficient rats. Manganese deficiency increased femur concentrations of copper, potassium, and zinc, and decreased the femur concentration of phosphorus; the changes were generally more marked in B-deprived rats. Additionally, there was a tendency for femur calcium (P<0.08) and magnesium (P<0.06) concentrations to be affected by an interaction between B and Mn. Only B deprivation affected the femur concentrations of B (decreased), iron (increased with the effect most marked in Mn-deficient rats) and molybdenum (decreased). Manganese deficiency alone only affected the femur concentration of Mn (decreased). The findings show that B and Mn can affect bone composition but the effect of one element can be modified by the dietary adequacy of the other.

Last Modified: 12/20/2014
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