|Javed Tariq, - UNIV OF IL|
|Dombrink Kurtzman, Mary Ann|
|Cote L Marie, - UNIV OF IL|
|Buck William B, - UNIV OF IL|
Submitted to: Journal of Veterinary Diagnostic Investigation
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: March 26, 1995
Publication Date: N/A
Interpretive Summary: Animal feed can sometimes contain molds capable of producing mycotoxins. Broiler chicks were given feed which had culture material of the mold, Fusarium proliferatum, containing fumonisin B1, fumonisin B2 and moniliformin. Blood from birds ingesting these diets had elevated levels of enzymes indicative of liver and kidney damage. Decreased amounts of red blood cells, hemoglobin and white blood cells, as well as an impaired antibody response, also occurred. Because culture material was fed, it is possible that additional, unidentified toxins may have been present.
Technical Abstract: Two-hundred twenty-eight male broiler chicks (Columbia x New Hampshire) were given feed amended with autoclaved culture material (CM) of Fusarium proliferatum containing fumonisin B1 (FB1) at 61, 193, 546 ppm, fumonisin B2 (FB2) at 14, 38 and 98 ppm and moniliformin at 66, 193 and 367 ppm in three separate feeding trials (amounts of toxin in each trial, respectively). Birds were started on amended rations at days 1, 7 and 21 and continued on their respective ration until they were 28 days old. Purified FB1 (125, 274 ppm) and moniliformin (27, 154 ppm) were given separately and in combination (137 and 77 ppm, respectively), starting on day 1 and continuing for 14 days. Of serum chemistry parameters, only glucose was significantly decreased. Significant increases were noted in serum cholesterol, sodium, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and gamma glutamyl transferase. Of the hematologic parameters, significant decreases were noted in red blood cell counts, hemoglobin, packed cell volume and white blood cell counts. Immunologic changes included impaired anti-Newcastle disease antibody hemagglutination inhibition titers associated with relative decreases in total serum globulins and increases in albumin/globulin ratios.