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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Publications at this Location » Publication #318079
Title: Discovery of a novel species of Bordetella

Author
item IVANOV, YURY - Pennsylvania State University
item LINZ, BODO - Pennsylvania State University
item NEWMAN, JEFF - Lycoming College
item Register, Karen
item LE GUYON, SOAZIG - Pennsylvania State University
item BOSCHERT, KEN - Washington University
item BRINKAC, LAUREN - J Craig Venter Institute
item LOSADA, LILIANA - J Craig Venter Institute
item HARVILL, ERIC - Pennsylvania State University

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 3/5/2015
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Bordetella species are Gram-negative coccobacilli. There are currently nine described species that constitute the genus Bordetella. Historically, this genus is subdivided into two groups of species: the “classical” and “non-classical” Bordetella. The classical Bordetella are the most studied group represented by respiratory pathogens B. pertussis and B. parapertussis—the two causative agents of “whooping cough” in humans—and B. bronchiseptica, which has a broad host range and is a causative agent of Kennel cough in dogs, atrophic rhinitis in pigs, snuffles in rabbits, and respiratory syndrome in immunocompromised humans. The non-classical bordetellae are less studied and consist of six species: B. hinzii, B. holmesii, B. petrii, B. avium, B. trematum, and B. ansorpii. Unlike the classical bordetellae, which infect and cause disease of the respiratory tract of their natural hosts, the non-classical species are associated with a wider variety of disease presentations. For example, B. hinzii is known to cause chronic cholangitis, bacteremia, or fatal septicemia in humans and respiratory disease in poultry and rodents. We have sequenced over 100 genomes of four Bordetella species, including B. pertussis, B. bronchiseptica, B. holmesii, and B. hinzii, and defined genomic diversity among classical and non-classical species. During these studies, we identified an isolate, 8-296-03, that shows a high degree of sequence divergence. Here, we present genomic and phenotypic evidence for this isolate, sufficient to convincingly propose it to be a novel species, which we propose to designate B. psudohinzii (“PSU”dohinzii).