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Title: Draft genome sequences of 53 genetically distinct isolates of Bordetella bronchiseptica representing 11 terrestrial and aquatic hosts

Author
item Register, Karen
item IVANOV, YURY - Pennsylvania State University
item JACOBS, NATHAN - Pennsylvania State University
item MEYERS, JESSICA - Pennsylvania State University
item GOODFIELD, LAURA - Pennsylvania State University
item MUSE, SARAH - Pennsylvania State University
item SMALLRIDGE, WILLIAM - Pennsylvania State University
item BRINKAC, LAUREN - J Craig Venter Institute
item KIM, MARIA - J Craig Venter Institute
item SANKA, RAVI - J Craig Venter Institute
item HARVILL, ERIC - Pennsylvania State University
item LOSADA, LILIANA - J Craig Venter Institute

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/6/2015
Publication Date: 5/1/2015
Publication URL: http://handle.nal.usda.gov/10113/61361
Citation: Register, K.B., Ivanov, Y., Jacobs, N., Meyers, J., Goodfield, L., Muse, S., Smallridge, W., Brinkac, L., Kim, M., Sanka, R., Harvill, E., Losada, L. 2015. Draft genome sequences of 53 genetically distinct isolates of Bordetella bronchiseptica representing 11 terrestrial and aquatic hosts. Genome Announcements. 3(2):e00152-15. DOI: 10.1128/genomeA.00152-15.

Interpretive Summary: Bordetella bronchiseptica is a widespread respiratory pathogen in a variety of wild and domesticated animals. Most frequently, it is a cause of respiratory disease in pigs and dogs but the bacterium is also an occasional zoonotic pathogen, with infants and immunocompromised individuals at highest risk. B. bronchiseptica has a remarkably broad host range as compared to other Bordetella species. Prior analyses suggest particular strains may preferentially infect and cause disease in one or a few hosts, but the genetic basis for host specificity or for host-specific virulence is currently unclear. Here we report the genome sequences of 53 genetically distinct isolates, acquired from a broad range of terrestrial and aquatic animals. These data will greatly facilitate ongoing efforts to better understand evolution, host adaptation and virulence mechanisms of B. bronchiseptica, potentially leading to novel diagnostic tools and vaccine approaches and improved disease prevention and management strategies.

Technical Abstract: Bordetella bronchiseptica infects a variety of mammalian and avian hosts. Here we report the genome sequences of 53 genetically distinct isolates, acquired from a broad range of terrestrial and aquatic animals. These data will greatly facilitate ongoing efforts to better understand evolution, host adaptation and virulence mechanisms of B. bronchiseptica.