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United States Department of Agriculture

Agricultural Research Service

Research Project: INTERVENTION STRATEGIES TO CONTROL NEWCASTLE DISEASE Title: Correlation between vaccination immune responses, viral shedding and transmission

item Miller, Patti

Research conducted cooperatively with:

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: February 8, 2014
Publication Date: N/A

Technical Abstract: Newcastle disease is a significant disease of poultry caused by virulent forms of Newcastle disease virus. It presents a recurrent problem worldwide despite the existence of good commercial vaccines. Here we describe studies conducted at SEPRL that demonstrate that homologous vaccines produce more effective immune responses that lead to reduced virus shedding. In addition we show here that the levels of humoral antibodies correlate with the capacity of viruses to prevent transmission. Heterologous vaccines are able to prevent disease and death from ND when enough time between vaccination and infection occurs. However, homologous vaccines were able to provide protection with less time between vaccination and infection and when smaller amounts of vaccine virus were used compared to the vaccines heterologous to the challenge.

Last Modified: 8/27/2015
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