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United States Department of Agriculture

Agricultural Research Service

Research Project: GENETIC AND BIOLOGICAL DETERMINANTS OF AVIAN TUMOR VIRUS PATHOGENICITY, TRANSMISSION, AND EVOLUTION

Location: Avian Disease and Oncology Laboratory

Title: Role of endogenous avian leukosis virus and serotype 2 Marek’s disease virus in enhancement of spontaneous lymphoid-leukosis-like tumors in chickens

Authors
item FADLY, ALY
item MAYS, JODY
item ZHANG, HUANMIN
item HUNT, HENRY

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: December 16, 2013
Publication Date: N/A

Technical Abstract: The influence of endogenous subgroup E avian Leukosis virus (ALV-E) and strain SB-1 of serotype 2 Marek’s disease virus (MDV) on the enhancement of spontaneous lymphoid leukosis (LL)-like tumors was studied in chickens of Avian Disease and Oncology Laboratory (ADOL) line named 0.TVB*S1, or RFS. This line of chickens lacks all endogenous virus genes and is susceptible to infection with all subgroups of ALV including subgroup E (ALV-E). The results suggest that the incidence of spontaneous LL-like tumors in chickens that harbor endogenous ALV was higher than in chickens that lack ALV-E following vaccination with serotype 2 MDV at hatch. The data suggest that both ALV-E and serotype 2 MDV play an important role in the enhancement of spontaneous LL-like tumors in certain lines of chickens.

Last Modified: 8/19/2014
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