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United States Department of Agriculture

Agricultural Research Service

Research Project: GENETIC ENHANCEMENT FOR RESISTANCE TO BIOTIC AND ABIOTIC STRESSES IN HARD WINTER WHEAT

Location: Hard Winter Wheat Genetics Research Unit

Title: A heterozygous moth genome provides insights into herbivory and detoxification

Authors
item You, Minsheng -
item Yue, Zhen -
item He, Weiyi -
item Yang, Xinhua -
item Yang, Guang -
item Xie, Miao -
item Zhan, Dongliang -
item Baxter, Simon -
item Vasseur, Liette -
item Gurr, Geoff -
item Douglas, Carl -
item Bai, Jianlin -
item Wang, Ping -
item Cui, Kai -
item Huang, Shiguo -
item Li, Xianchun -
item Zhou, Qing -
item Wu, Zhangyan -
item Chen, Qilin -
item Liu, Chunhui -
item Wang, Bo -
item Li, Xiaojing -
item Xu, Xuifeng -
item Lu, Changxin -
item Hu, Min -
item Davey, John -
item Smith, Sandy -
item Chen, Ming-Shun
item Xia, Xiaofeng -
item Tang, Weiqi -
item Ke, Fushi -
item Zheng, Dandan -
item Hu, Yulan -
item Song, Fengqin -
item You, Yanchun -
item Ma, Xiaoli -
item Peng, Lu -
item Zheng, Yunkai -
item Liang, Yong -
item Chen, Yaqiong -
item Yu, Liying -
item Zhang, Younan -
item Liu, Yuanyuan -
item Li, Guoqing -
item Fang, Lin -
item Li, Jingxiang -
item Zhou, Xin -
item Lou, Yadan -
item Gou, Caiyun -
item Wang, Junyi -
item Wang, Jian -
item Yang, Huanming -
item Wang, Jun -

Submitted to: Nature Genetics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: December 12, 2012
Publication Date: January 13, 2013
Repository URL: http://www.nature.com/ng/journal/v45/n2/abs/ng.2524.html
Citation: You, M., Yue, Z., He, W., Yang, X., Yang, G., Xie, M., Zhan, D., Baxter, S.W., Vasseur, L., Gurr, G.M., Douglas, C.J., Bai, J., Wang, P., Cui, K., Huang, S., Li, X., Zhou, Q., Wu, Z., Chen, Q., Liu, C., Wang, B., Li, X., Xu, X., Lu, C., Hu, M., Davey, J.W., Smith, S.M., Chen, M., Xia, X., Tang, W., Ke, F., Zheng, D., Hu, Y., Song, F., You, Y., Ma, X., Peng, L., Zheng, Y., Liang, Y., Chen, Y., Yu, L., Zhang, Y., Liu, Y., Li, G., Fang, L., Li, J., Zhou, X., Lou, Y., Gou, C., Wang, J., Wang, J., Yang, H., Wang, J. 2013. A heterozygous moth genome provides insights into herbivory and detoxification. Nature Genetics. doi:10.1038/ng.2524.

Interpretive Summary: The diamondback moth is a serious pest of vegetables worldwide. The insect feeds on plants that produce glucosinolates, which are toxic to other types of insects. The diamondback moth is also highly capable of developing new strains that are resistant to various synthetic chemical pesticides. This study sequenced and analyzed the whole genome of the diamondback moth. The genome is highly heterogeneous and contains 18,071 protein-coding and 1,412 unique genes. Several gene families associated with perception and the detoxification of plant defense compounds are expanded in comparison with those of other insect species. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to be involved in the development of insecticide resistance. This work revealed the genetic and molecular bases for an herbivore to adapt to toxic chemicals of host plants.

Technical Abstract: How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.

Last Modified: 9/10/2014
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