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United States Department of Agriculture

Agricultural Research Service

Title: Rice Bran Phytochemicals and Dietary Colon Chemoprevention Teamwork

item Borreson, Erica -
item Forster, Genevieve -
item Kumar, Ajay -
item Keller, Amy -
item Chen, Ming-Hsuan
item McClung, Anna
item McClung, Anna
item Weir, Tiffany -
item Wdowik, Melissa -
item Ryan, Elizabeth -

Submitted to: Rice Technical Working Group Meeting Proceedings
Publication Type: Proceedings
Publication Acceptance Date: January 27, 2012
Publication Date: N/A

Technical Abstract: Rice Bran Phytochemicals and Dietary Colon Chemoprevention Teamwork Erica Borreson1,2, Genevieve Forster1 Ajay Kumar1, Amy Keller1, Ming-Hsuan Chen3, Anna McClung3, Tiffany L. Weir4, Melissa Wdowik4, Regina J. Brown5, and Elizabeth P. Ryan1,2,4 Department of Clinical Sciences1, Colorado School of Public Health2, USDA-ARS Dale Bumpers Rice Research Unit3, Department of Food Science and Human Nutrition4, Poudre Valley Health 5 A growing body of evidence supports that dietary rice bran exhibits gastrointestinal cancer control and prevention activity using carcinogen induced animal models and human colon cancer cell lines. Our laboratory has recently reported metabolomic differences in rice from globally and genetically distinct varieties, and we hypothesize that bran compounds from these different rice cultivars exhibit variability for inhibition of colon cancer viability. Bioactive rice bran components, including tocotrienols and tocopherols (alpha, gamma, delta), gamma oryzanol, ferulic acid, total phenolics and fatty acid profiles were quantified from 20 diverse varieties using biochemical assays, HPLC and GC-MS. Seven varieties were selected that showed a range of total bran oil content (6-16% total lipids) and were analyzed for differences in colon cancer viability in vitro by alamar blue staining and MTS assays. Correlation analysis was performed to identify significant associations between bioactive compounds and colon cancer growth inhibition. Differences in the ratios and stoichiometry of rice bran components support potential for additive/synergistic effects of rice bran. Rice bran contains a number of colon chemopreventive agents that target multiple key hallmarks and metabolic mechanisms in cancer, and dietary intervention strategies with whole rice bran consumption are warranted for enhanced efficacy. Pilot data from a prospective, placebo controlled, dietary rice bran intervention study titled ‘BENEFIT’ (Bran-rice Enriching Nutritional Eating For Intestinal health Trial) demonstrates translational feasibility of increasing rice bran intake in healthy adults and colon cancer survivors. The accessibility, affordability, and availability of dietary rice bran further support the strong public health impact potential for novel “phytochemical teamwork” based colon cancer control and chemoprevention strategies. This work was supported by NCI-Cancer Prevention Grant program, 5R03CA150070-2.

Last Modified: 7/25/2014
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