Technical Abstract: The goal of postharvest grain drying, handling, and storage operations is to preserve the harvest quality of the grain and to add value by removing impurities and identifying and segregating lots with special characteristics when appropriate. For agricultural products, quality loss may occur due to poor drying techniques, improper handling of the products, or lack of proper storage environments resulting in deterioration of the product from such causes as cracking, splitting, mold growth, insect damage, sprouting, loss of germination, and dry matter loss from respiration. Large grains such as corn, especially when dried at high temperatures, are particularly susceptible to physical damage during handling. Physical damage also makes grain more susceptible to invasion by storage fungi and insects. Postharvest drying, handling, and storage operations can be designed and managed to minimize or eliminate quality losses and produce a higher value product than at harvest. The purpose of this chapter is to guide grain managers on optimizing these operations to preserve grain quality and enhance grain value.