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ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #284519
Title: Anti-cancer scopes and associated mechanisms of Scutellaria extract and flavonoid wogonin

Author
item PATEL, PARAS - Wayne State University
item JOSHEE, NIRMAL - Wayne State University
item Rimando, Agnes
item PARAJULI, PRAHLAD - Wayne State University

Submitted to: Current Cancer Therapy Reviews
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/29/2012
Publication Date: 2/1/2013
Citation: Patel, P., Joshee, N., Rimando, A.M., Parajuli, P. 2013. Anti-cancer scopes and associated mechanisms of Scutellaria extract and flavonoid wogonin. Current Cancer Therapy Reviews. 9(1):34-42.

Interpretive Summary: Scutellaria plants have been used in Eastern traditional medicine as well in the Americas for the treatment of several human ailments, including cancer. Crude extracts or compounds from Scutellaria known as flavonoids have been scientifically studied for potential anti-cancer activity using cell as well as animal models of various cancers, including breast cancer, prostate cancer, ovarian cancer and cancer of the nervous system. Phase I clinical studies have also been conducted to study the toxicity/efficacy of Scutellaria extract in patients whose breast cancer has spread. This article is a brief review of pertinent research articles on the anti-tumor efficacy of Scutellaria extracts, particularly those containing the compound wogonin. The potential significance of Scutellaria flavonoids as an adjuvant therapy for malignant tumors is discussed.

Technical Abstract: Extracts of Scutellaria species have been used in Eastern traditional medicine as well in the Americas for the treatment of several human ailments, including cancer. Crude extracts or flavonoids derived from Scutellaria have been scientifically studied for potential anti-cancer activity using in vitro as well as animal models of various cancers, including breast cancer, prostate cancer, ovarian cancer and malignant gliomas. Phase I clinical studies have also been conducted to study the toxicity/efficacy of Scutellaria extract in patients with metastatic breast cancer. This article is a succinct review of pertinent research articles on the anti-tumor efficacy and associated molecular mechanisms of Scutellaria extracts, particularly those containing the flavonoid wogonin. The potential significance of Scutellaria flavonoids as an adjuvant therapy for malignant tumors is discussed.