Skip to main content
ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Biosciences & Biotechnology Laboratory » Research » Publications at this Location » Publication #279530
Title: Recent progress in understanding host mucosal response to avian coccidiosis and development of alternative strategies to mitigate the use of antibiotics in animal production

Author
item Lillehoj, Hyun
item Lee, Sung
item JANG, SEUNG - Research Institute Of Health And Environment
item Kim, Duk Kyung
item LEE, KYUNG - Animal, Plant And Fisheries Quarantine And Inspection Agency (QIA)

Submitted to: Korean Journal of Poultry Science
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/2/2012
Publication Date: 5/30/2012
Citation: Lillehoj, H.S., Lee, S.H., Jang, S.I., Kim, D., Lee, K.W. 2012. Recent progress in understanding host mucosal response to avian coccidiosis and development of alternative strategies to mitigate the use of antibiotics in animal production. Korean Journal of Poultry Science. 38:275-284.

Interpretive Summary: Confronting the increased demand for poultry food products are emerging field diseases, increasing regulatory bans of antimicrobial growth promoters, high-density growth conditions, and waste management. Although biotechnology offers solutions to some of these challenges, basic studies are needed to better understand the complex interaction between the intestinal microbiome, host immunity and the environment. In this paper, We discuss the current understanding of the host innate immune response to intestinal parasites and provide new ideas on developing a dietary strategy to mitigate the use of antibiotics using plant-derived phytonutrients. This new information will help industry scientists to devise novel methods to control poultry gut diseases and will facilitate the design of future nutritional interventions and vaccination strategies for coccidiosis.

Technical Abstract: As the world population grows and developing countries become more affluent, the global consumption of meat will increase by more than 50% within the next 10 years. Confronting the increased demand for poultry food products are emerging field diseases, increasing regulatory bans of antimicrobial growth promoters, high-density growth conditions, and waste management. Although biotechnology offers solutions to some of these challenges, basic studies are needed to better understand the complex interaction between the intestinal microbiome, host immunity and the environment. This presentation will focus on emerging strategies to enhance gut immunity and to decrease economic losses due to poultry diseases. This presentation will highlight recent developments in coccidiosis research and provide information on host immunity, immunomodulation, and the latest advances in live and recombinant vaccine development against coccidiosis. Such information will magnify our understanding of host-parasite biology, mucosal immunology, and design of future nutritional interventions and vaccination strategies for coccidiosis.