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United States Department of Agriculture

Agricultural Research Service

Research Project: TECHNOLOGIES FOR THE DETECTION OF CHEMICAL AND BIOLOGICAL CONTAMINANTS IN FOODS

Location: Residue Chemistry and Predictive Microbiology

Title: A multiclass multiresidue LC-MS/MS method for analysis of veterinary drugs in bovine kidney

Authors
item Schneider, Marilyn
item Lehotay, Steven
item Lightfield, Alan

Submitted to: Euroresidue Conference Proceedings
Publication Type: Proceedings
Publication Acceptance Date: December 7, 2011
Publication Date: May 14, 2012
Citation: Schneider, M.J., Lehotay, S.J., Lightfield, A.R. 2012. A multiclass multiresidue LC-MS/MS method for analysis of veterinary drugs in bovine kidney. Euroresidue Conference Proceedings. 2:515.

Technical Abstract: The increased efficiency permitted by multiclass, multiresidue methods has made such approaches very attractive to laboratories involved in monitoring veterinary drug residues in animal tissues. In this current work, evaluation of a multiclass multiresidue LC-MS/MS method in bovine kidney is described using 5 replicates over each of three days. Over 100 analytes including quinolones, sulfonamides, tetracyclines, macrolides, Beta-lactams, cephalosporins, anthelminthics, Beta-agonists, thyreostats, and tranquilizers are evaluated using the optimized method at fortification levels of 10, 50, 100 and 200 ng/g. While not all analytes perform well, good recoveries can be obtained, and these values, along with the lowest calibration standard levels for each analyte are reported. This method can provide a simple and useful multiclass multiresidue option for those involved in drug residue analysis in animal tissues.

Last Modified: 12/24/2014
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