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United States Department of Agriculture

Agricultural Research Service

Research Project: INTEGRATED APPROACHES FOR IMPROVING THE EFFICIENCY AND SUSTAINABILITY OF MORONE AND OTHER WARM WATER FISH PRODUCTION

Location: Harry K. Dupree Stuttgart National Aquaculture Research Center

Title: Subsets of ATP-sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression

Authors
item Bodenstine, Thomas -
item Vaidya, Kedar -
item Ismail, Aimen -
item BECK, BENJAMIN
item Diers, Anne -
item Edmonds, Mick -
item Kirsammer, Gina -
item Landar, Aimee -

Submitted to: Acarology International Congress Proceedings
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: November 14, 2011
Publication Date: November 24, 2011
Citation: Bodenstine, T.M., Vaidya, K.S., Ismail, A., Beck, B.H., Diers, A.R., Edmonds, M.D., Kirsammer, G., Landar, A. 2011. Subsets of ATP-sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression. Acarology International Congress Proceedings. Available: doi:10.1016/j.febslet.2011.11.017.

Interpretive Summary: Gap junctional intercellular communication (GJIC) is a process whereby cells share molecules and nutrients with each other by physical contact through cell membrane pores. In tumor cells, GJIC is often altered, suggesting that this process may be important in the context of cancer. Certain ion channels, termed KATP channels, are important in maintaining the stability of the cell membrane and have been shown to be closely linked to GJIC; however little is known about the precise mechanistic relationship between GJIC and KATP channels. In this study, we report the effects of the treatment of different cancer cell types with inhibitors of KATP channels. When certain component parts of the KATP channels were inhibited, GJIC increased. These findings highlight novel off-target effects of KATP inhibitors and may be of utility in clinical settings in the future.

Technical Abstract: Gap junctional intercellular communication (GJIC) is a process whereby cells share molecules and nutrients with each other by physical contact through cell membrane pores. In tumor cells, GJIC is often altered, suggesting that this process may be important in the context of cancer. Certain ion channels, termed KATP channels, are important in maintaining the stability of the cell membrane and have been shown to be closely linked to GJIC; however little is known about the precise mechanistic relationship between GJIC and KATP channels. In this study, we report the effects of the treatment of different cancer cell types with inhibitors of KATP channels. When certain component parts of the KATP channels were inhibited, GJIC increased. These findings highlight novel off-target effects of KATP inhibitors and may be of utility in clinical settings in the future.

Last Modified: 7/28/2014
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