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Title: Association, effects and validation of polymorphisms within the NCAPG - LCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle

Author
item Lindholm-Perry, Amanda
item SEXTEN, ANDREA - Kansas State University
item Kuehn, Larry
item Smith, Timothy - Tim
item King, David - Andy
item Shackelford, Steven
item Wheeler, Tommy
item FERRELL, CALVIN - Retired ARS Employee
item JENKINS, THOMAS - Retired ARS Employee
item Snelling, Warren
item Freetly, Harvey

Submitted to: BioMed Central (BMC) Genetics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/14/2011
Publication Date: 12/20/2011
Citation: Lindholm-Perry, A.K., Sexten, A.K., Kuehn, L.A., Smith, T.P., King, D.A., Shackelford, S.D., Wheeler, T.L., Ferrell, C.L., Jenkins, T.G., Snelling, W.M., Freetly, H.C. 2011. Association, effects and validation of polymorphisms within the NCAPG - LCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle. BioMed Central (BMC) Genetics. 12:103.

Interpretive Summary: A large region on bovine chromosome 6 was previously identified that contains candidate genes for beef cattle average daily feed intake (ADFI) or average daily gain (ADG). Genetic markers that are informative over many breeds of cattle for these traits will allow producers to genetically select for animals that consume less feed and/or produce animals with optimal production weights and should have a positive economic impact for beef cattle producers. The goal of the present study was to develop and examine additional markers that are optimal for distinguishing variation. Twelve markers located within a narrow region that included two genes known to be involved with cattle growth and human height were significantly associated with feed intake and gain phenotypes. These markers were also significant for hot carcass weight, ribeye area, and adjusted fat thickness suggesting that a gene in this region contributes to lean growth and reduced fat deposition. To validate these markers further, they were genotyped on a separate crossbred population of animals consisting of 14 beef cattle breeds. Two markers within the gene associated with human height were significantly associated with ADG. These two markers may be more robust for the prediction of ADG across multiple breeds and populations of cattle.

Technical Abstract: Background: In a previously reported genome-wide association study based on a high-density bovine SNP genotyping array, 8 SNP were nominally associated (P