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United States Department of Agriculture

Agricultural Research Service

Research Project: AGRICULTURAL PRACTICES, ECOLOGICAL AND VARIETAL EFFECTS ON AFLATOXINS AND OTHER MYCOTOXINS IN CORN

Location: Biological Control of Pests Research Unit

Title: Characterization Adn Biological Activity of Secondary Metabolites from Armillaria Tabescens

Authors
item Herath, Bandera -
item Jacob, Melisa -
item ABBAS, HAMED
item Wilson, A -
item Nanayakkaara, Dhammika -

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: July 5, 2011
Publication Date: N/A

Technical Abstract: Ethyl acetate extracts from liquid cultures of Armillaria tabescens showed good antimicrobial activity against Candida albicans, Cryptococcus neoformans, Escherichia coli and Mycobacterium intracellulare. Chemical analyses of extract constituents led to the isolation and identification of two new compounds, emestrin-G (1) and a new diastereomer of the cephalosporolide series, cephalosporolide-J (2), along with seven other previously known compounds, emestrin (3), emestrin-B (4) cephalosporolide F (5), decarestrictine-C2 (6), erithritol diacetate (7), ergosta-5-7-22-triene-3-ol (8) and ergosta-5-22-diene-3-ol (9). Structural elucidation of all compounds was carried out by NMR and MS analysis. Compounds 1, 3 and 4 were identified as the compounds responsible for the observed antimicrobial activity.

Last Modified: 8/19/2014
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