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United States Department of Agriculture

Agricultural Research Service

Research Project: NEW BIOACTIVE AND BIOBASED PRODUCTS FROM PLANT CELL WALL POLYSACCHARIDES IN SUGAR BEET PULP, CITRUS PEEL AND OTHER ... PROCESSING RESIDUES

Location: Dairy and Functional Foods

Title: Pectin/zein hydrogels for the delivery of drugs and nutrients

Authors
item Muhidinova, Z -
item Teshaev, Kh -
item Nasridinov, A -
item Liu, Linshu

Submitted to: Food Hydrocolloids Conference Proceedings
Publication Type: Book / Chapter
Publication Acceptance Date: June 17, 2011
Publication Date: N/A

Technical Abstract: Two pectin/zein coacervates were prepared with either calcium ions or zinc ions. Piroxicam, a non-steroidal anti-inflammatory drug, was encapsulated. It was found that at lower solution pH the release of piroxicam displayed a near zero order kinetics, whether the coacervates were cross-linked with calcium or zinc. At neutral solution pH, the release of piroxicam from zinc cross-linked coacervates showed a much longer duration than that from calcium cross-linked ones. This may be attributed to the difference in swelling degree between the two types of drug carriers. Zinc cross-linked one swelled less at neutral pH than the calcium cross-linked ones, as revealed by microscopic examination and solution turbidity measurements.

Last Modified: 10/21/2014
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